The University of Manchester, UK
PhD, Molecular Biology
1999 – 2003
The University of Manchester, UK
BSc, Chemistry with Medicinal Chemistry
1996-1999
Chemical Biology is the incorporation of a chemical approach toward understanding biological processes and the molecular characterization of biological macromolecules. In recent years there is an increasing demand for novel, more effective therapeutic agents. Comprehending the mechanism of action of lead compounds and their interaction with biological targets is a fundamental aspect of designing such agents.
RTIN’s chemical biology research area is interested in investigating how small molecules bind to their targets in both prokaryotic and eukaryotic systems in order to design novel affinity-binding detection methodologies. Such methods are applied towards structure and ligand-based drug design, targeting selected biological processes for the discovery of new therapeutic entities.
“Green” pathways are also being developed for the synthesis of small bioactive molecules and their subsequent activity evaluation.
The synthesis and assessment of novel nanoparticles as carrier systems for the targeted delivery of antibacterial agents is also undertaken.
Dr. Georgia Kythreoti graduated with first-class honours, BSc in Chemistry and Medicinal Chemistry from the Department of Chemistry, The University of Manchester, UK. She acquired her Doctor of Philosophy title also from the University of Manchester, where she focused on the development of green routes towards the synthesis of a novel cephalosporin intermediate for a semi-synthetic preparation of cephalosporin antibiotic production.
Dr. Kythreoti is a faculty member of the Department of Science and Mathematics since 2021, where she is teaching Chemistry courses at the Biomedical Sciences Program and supervises capstone projects related to her research interests. She is also involved in research collaborations with the National Centre for Scientific Research “Demokritos.”
She has extensive experience in both basic and applied research, exemplified by her publication record and contribution, as an investor, in patented projects. Her research interests include rational drug design studies for the development of novel bioactive compounds, the development of affinity and functional assay methodologies for a variety of biological systems of interest, semi-synthetic approaches towards green synthesis of antibiotic intermediates, as well as the assessment of dendritic polymer nanoparticles as novel delivery systems for antimicrobial agents.