ACG 150

Overview

The Chemical Biology Lab engages in high-impact research on the application of chemical tools in drug discovery. Interdisciplinary approaches are employed aiming to develop novel therapeutic agents and identify novel naturally occurring compounds for potential pharmaceutical, cosmetic, or nutritional applications. In parallel, the lab integrates principles of environmental science and sustainability, emphasizing green methodologies and the responsible sourcing and application of natural products.

The laboratory comprises of state-of-the-art equipment supporting such an interdisciplinary approach, including: Antibacterial Photodynamic Therapy equipment, extraction, separation and analysis equipment such as High Pressure Liquid Chromatography, UV/Vis spectrophotometry, Fluorescence and Luminescence high-throughput screening and microorganisms culture growth equipment.

Laboratory members are involved in a number of research projects and maintain several research collaborations.

 

Areas of Interest

The areas of interest that the laboratory members are engaged in range from pharmaceutical, nutritional, cosmetic, and medical applications to environmental studies. Current research projects and future directions are implemented and envisioned via internal and external collaborations.

  • Study of photosensitizers for Antibacterial Photodynamic Therapy (aPDT)
  • Identification and evaluation of novel compounds as antibacterial agents. Incorporation of small molecules with antibacterial potencies into hybrid nanoparticles for the preparation of materials intended for medical uses.
  • Screening of extracts for antibacterial properties for the isolation and development of novel antibiotics or lead structures.
  • Studies of natural products and their analogues as anti-oxidant or anti-inflammatory agents with potential applications in the pharmaceutical, cosmetics, and nutritional supplements industry.
  • Identifying molecular mechanisms of disease and potential therapeutic targets.
  • Design and discover drugs and screen compound libraries
  • Analysis of samples obtained from archeological excavations, in order to identify plants used for medicinal purposes in antiquity, determine their activities and possibly isolate bioactive structures that can be used once more as therapeutic agents.
  • Bioprospecting and phytochemical analysis of underexplored plant species to discover novel bioactive compounds.

 

Facilities and Lab infrastructure

The Chemical Biology Lab is located at the Deree campus, with easy access to all the campus services and facilities e.g., libraries, sister science labs, auditoriums, administrative services, institutes and centers. The lab is equipped with work and meeting spaces for its members and collaborators and state-of-the-art equipment supporting a variety of research projects.

 

Antibacterial Photodynamic Therapy Equipment

Extraction and Separation

 

Analysis Equipment

Microorganisms Culture Growth and High-Throughput Screening

Mission

To advance drug discovery and natural products research through innovative approaches and applications. We promote transdisciplinary integration for the development of green and sustainable products and methodologies that will positively impact our society.

Vision

The Chemical Biology Lab envisions advancing human health through the development of innovative tools and therapeutic agents. By fostering interdisciplinary collaboration and integrating cutting-edge methodologies, we aim to be a leading force in translating fundamental understanding of biological processes into real-world biomedical solutions.

Leadership

Georgia Kythreoti, PhD
Assistant Professor, Chemical Biology Department of Science and Mathematics, School of Liberal Arts and Sciences, Deree

ChemBio Lab Members

Alexia Victoria Polissidis, PhD
Biomedical Sciences
Dr. Marina Sagnou
Associate Researcher at the Institute of Biosciences and applications (IBA) of NCSR “Demokritos”
Dr. Michael Valahas
Assistant Professor, Department of Science and Mathematics and the International Honors Program, Deree - ACG
Erika Lego
RTIN Scholar | Work-Study Intern
Kleopatra Gkoni
Work-Study Intern
Sofia Dafnomili
RTIN Scholar | Undergraduate Capstone Student
Maria Veisllari
Undergraduate Capstone Student
VIEW MORE

ChemBio Lab Alumni

Ariadni Athanasiou
Undergraduate Capstone Student
Angeliki Kokkali
Undergraduate Capstone Student
Zafeiris Konstantinos Drakopoulos
Undergraduate Capstone Student

News

ASBMB Today: Computational tool helps scientists create novel bug sprays

May 20, 2025

Learn more about this event here.

ACG Student Symposium

May 22-23, 2025

Read more about this event here.

Deree Science Day

March 15, 2025

Learn more about the event here.

Collaborators

  • Structural Studies of Biomolecules and Pharmaceuticals Laboratory, National Center of Scientific Research “Demokritos”
  • Laboratory of Natural Products Synthesis & Bioorganic Chemistry, National Center of Scientific Research “Demokritos”
  • Laboratory of Brain Exosomes and Pathology – ExoBrain, National Center of Scientific Research “Demokritos”
  • Institute of Chemical Biology, National Hellenic Research Foundation
  • Functional Nanomaterials of Organized Structure Laboratory, National Center of Scientific Research “Demokritos”
  • Laboratory of Insects & Parasites of Medical Importance, Benaki Phytopathological Institute
  • Navarino Environmental Observatory
  • Biomedical Optics and Applied Biophysics Laboratory of the School of Electrical and Computer Engineering, NTUA, Athesn, Greece
  • Nuclearpharm PC, Athens, Greece
  • Department of Clinical Microbiology, Athens Medical School, Aeginition Hospital, Athens, Greece.
  • Laboratory of Chemistry, Department of Food Science & Human Nutrition, Agricultural University of Athens
  • Laboratory of Enzyme Technology, Department of Agricultural Biotechnology, Agricultural University of Athens

Recent Publications

Kythreoti, G. et al. “Natural volatiles preventing mosquito biting: An integrated screening platform for accelerated discovery of ORco antagonists”, J Biol Chem., 2024, 300(12), 107939. doi: 10.1016/j.jbc.2024.107939

 

Papadopoulou, P. et al. “Anti-inflammatory and Neuroprotective Polyphenols Derived from the European olive tree, Olea europaea L, in Long COVID and other Conditions Involving Cognitive Impairment”, International Journal of Molecular Sciences, 2024, 25, 11040. doi: 10.3390/ijms252011040

 

Nakos Bimpos, M., et al. “Alpha-synuclein-induced stress sensitivity renders the Parkinson’s disease brain susceptible to neurodegeneration”. Acta Neuropathol Commun. 2024, (1):100. doi: 10.1186/s40478-024-01797-w.

 

Kythreoti, G. et al. “Volatile allosteric antagonists of mosquito odorant receptors inhibit human-host attraction’, J Biol Chem., 2021, 296:100172. doi: 10.1074/jbc.RA120.016557.

 

Heliopoulos, N.S. et al. “Cytotoxicity Effects of Water-Soluble Multi-Walled Carbon Nanotubes Decorated with Quaternized Hyperbranched Poly(ethyleneimine) Derivatives on Autotrophic and Heterotrophic Gram-Negative Bacteria”, Pharmaceuticals, 2020, 13(10), E293. doi: 10.3390/ph13100293

* The above paper was chosen by the editors to be reprinted in a Book entitled, “Novel Antibacterial Agents”, Pharmaceuticals, 2022, MDPI. doi: 10.3390/ph14040382

 

Kythreoti, G. and Vourloumis, D. “A Homo sapiens cytoplasmic ribosomal decoding A-site affinity screen evaluating aminoglycoside- and analogues-binding”, Anal. Biochem., 2011, 412, issue 1, 102-107. doi: 10.1016/j.ab.2011.01.013

 

Koutsokali, M. and Valahas, M. ”Anaerobic and Aerobic Respiration in Yeast: Small-Scale Variations on a Classic Laboratory Activity.” Journal of Chemical Education, 2020, 97 (4) , 1041-1047. doi:10.1021/acs.jchemed.9b00994

 

Mangana, M., Lambrinidis, G., Kostakis, I. K., Kalpaktsi, I., Sagnou, M., Nicolaou, C., Mikros, E., Chatzipanagiotou, S., & Ioannidis, A. (2025). Towards New Scaffolds for Antimicrobial Activity—In Silico/In Vitro Workflow Introducing New Lead Compounds. Antibiotics, 14(1), 11. https://doi.org/10.3390/antibiotics14010011

 

Karagianni, A., Timotheatou, S., Manakou, V., Moutselos, A., Athanasopoulos, A., Politopoulos, K., Matiadis, D., Sagnou, M., & Alexandratou, E. (2024). Monocarbonyl curcuminoids as potential photosensitizers in photodynamic therapy against skin cancer. Journal of photochemistry and photobiology. B, Biology, 260, 113025. Advance online publication. https://doi.org/10.1016/j.jphotobiol.2024.113025

 

Frei, A.; Elliott, A. G.; Kan, A., Dinh, H.; Bräse, S.; Bruce, A. E.; Bruce, M. R.; Chen F.; Humaidy, D.; Jung, N.; King, A. P.; Lye, P. G.; Maliszewska, H. K.; Mansour, A. M.; Matiadis, D.;Muñoz, M. P.; Pai, T. Y.;Pokhrel, S.; Sadler, P. J.; Sagnou, M.; Taylor, M.; Wilson, J.J.; Woods, D.; Zuegg, J.; Meyer, W.; Cain, A.K; Cooper, M. A.; Blaskovich, M. A. T. (2022). Metal Complexes as Antifungals? From a Crowd-Sourced Compound Library to the First In Vivo Experiments. JACS Au, 2, 2277–2294. https://doi.org/10.1021/jacsau.2c00308

 

Halevas, E.; Arvanitidou, M.; Mavroidi, B.; Hatzidimitriou, A. G.; Politopoulos, K.; Alexandratou, E.; Pelecanou, M.; Sagnou, M.  (2021) A novel curcumin gallium complex as photosensitizer in photodynamic therapy: Synthesis, structural and physicochemical characterization, photophysical properties and in vitro studies against breast cancer cells, J Mol Struct, 1240, 130485, https://doi.org/10.1016/j.molstruc.2021.130485

 

Kazantzis, K.T.; Koutsonikoli, K.; Mavroidi, B.; Zachariadis, M.; Alexiou, P.; Pelecanou, M.; Politopoulos, K.; Alexandratou, E.;* Sagnou, M. (2020). Curcumin derivatives as photosensitizers in Photodynamic Therapy: photophysical properties and in vitro studies with prostate cancer cells, Photochem. Photobiol. Sci., 19, 193. https://doi.org/10.1039/C9PP00375D